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What is Hydrocodone?

Hydrocodone is a generic opioid drug used to relieve severe pain. Hydrocodone is a narcotic pain drug that binds to the opioid receptors in the CNS and alters the way pain is perceived. These drug brand names include Zohydro ER and Hysingla ER, both extended-release drugs and long-acting forms of Hydrocodone. Typically, patients who require pain relief for extended duration use Hydrocodone. Several other medications contain Hydrocodone. Commonly Hydrocodone is dispensed as the combination of ibuprofen/hydrocodone or acetaminophen/hydrocodone for pain severe enough to need an opioid. Hydrocodone is also formulated in combination with homatropine methyl bromide for cough suppression. The side effects and risks associated with most Hydrocodone formulations come from the Hydrocodone’s opioid and acetaminophen components.

Hydrocodone reduces the overall activity of the CNS, which includes blood pressure, heart rate, and respiration. This slowing of the central nervous system is why it is imperative for patients to follow dosing instructions. Patients must buy Hydrocodone online and take it exactly as prescribed.

Hydrocodone is primarily used to relieve pain because it contains chemicals that relax the body. Additionally, Hydrocodone can also act as an antitussive or cough suppressant, and it can be used to treat symptoms of the common cold. 


Hydrocodone should only be used for severe pain when non-opioid medicine does not help. Hydrocodone is habit-forming, and patients may experience severe withdrawal symptoms with Hydrocodone.

One should only take a high dosage of Hydrocodone ( above 40 mg per tablet) if the person has regularly been taking moderate amounts of opioid pain relief medicines. A large dosage of Hydrocodone can also cause overdose or even death. You should, therefore, avoid taking Hydrocodone for mild pain. 

Dosages of Hydrocodone

The usual starting dose of Hydrocodone for patients who have not taken any opioid in the past or patients with severe pain unmanageable by opioids of lower strength is 10 mg. Some patients can benefit from an initial dose of 5 mg to reduce the occurrence of side effects. 

Hydrocodone should not be used in minor patients.

Hydrocodone 120 mg, 80 mg, and 60 mg tablets should not be used in patients not previously exposed to opioids. These tablet strengths may cause dangerous respiratory depression when given to opioid naïve patients.

Adult Hydrocodone dosage (aged 18 years and older )

Five milligrams or 2.5 milligrams hydrocodone / 300 milligrams or 325 milligrams acetaminophen: The usual dosage is 1–2 tablets taken every 3–5 hours as required. The maximum dosage is six tablets a day.

7.5 milligrams or 10 milligrams hydrocodone / 300 milligrams or 325 milligrams acetaminophen: The usual dosage is one tablet taken every 4–5 hours as required. The maximum dosage is eight tablets per day.

Child Hydrocodone dosage (aged 0–18 years)

Dosage for patients younger than 18 years has not been established.

Things to know before using Hydrocodone

Patients with the following conditions must talk to their doctor about if Hydrocodone is safe for their intake.

  • Patients with head injury: If one has a head injury, Hydrocodone can cause increased pressure in the brain and can cause breathing issues.
  • Patients with stomach problems: Patients must be cautious taking Hydrocodone if having constipation, ulcerative colitis, or intestinal obstruction. This drug can worsen symptoms in such cases.
  • Patients with severe kidney disease: Hydrocodone can build up in the body, which can cause breathlessness and other side effects.
  • Patients with lung disease: If one has lung disease, he might have felt breathlessness after taking Hydrocodone.
  • Patients having severe liver disease: If one has severe liver disease, the risk of liver failure increases after taking Hydrocodone. Hydrocodone can build up in the body, which can cause breathlessness and other side effects.
  • Patients with prostate enlargement: If one has an enlarged prostate, taking Hydrocodone can cause increased difficulty in urination.
  • Patients with asthma: If one has uncontrolled or severe asthma, it is advisable not to take Hydrocodone without talking to the doctor. Such patients may have to take the first few doses of Hydrocodone in a monitored setting.

How should I take Hydrocodone?

One can take Hydrocodone with or without food, and patients usually take it every four to six hours. You must take this medicine with food in case you experience nausea. You can discuss with your doctor other techniques to control nausea. It would be best to swallow whole Hydrocodone tablets and not crush, chew, break, or dissolve them, leading to Hydrocodone overdose by releasing all of the medicine at once. Take only a single Hydrocodone tablet at a time to ensure you do not get choked if your prescribed dosage is for more than one tablet.

For adults over 18 years:

It would be best if you took Hydrocodone tablets at an interval of 4 to 6 hours. The dosage depends on the severity of the pain. It also depends on the patient’s previous history of requirements of analgesic.

Before starting treatment with Hydrocodone, doctors must discuss with patients and put a strategy to end therapy with Hydrocodone to reduce the possible risk of drug withdrawal syndrome.

Usually, the minimum effective dosage for analgesia should be selected. With the increased severity of pain, the dosage of Hydrocodone tablets should be increased, using the different tablet strengths to achieve pain relief in patients. The correct dosage for any patient is that which controls the pain for a total of twelve hours. Patients must be titrated to pain relief unless uncontrolled extreme drug reactions prevent this. If there is a necessity for higher doses, increments of 25% – 50% should be made.

What should I avoid while taking Hydrocodone?

One should not drink alcohol during the treatment with Hydrocodone because that may increase the risk of experiencing adverse side effects. Another essential thing to know is that Hydrocodone may cause severe breathing problems, especially during the first or second day of consumption. 

Also, share with your doctor if you are pregnant or are planning to be pregnant because Hydrocodone could lead to severe withdrawal symptoms in the baby. Inform the baby’s doctor immediately if the baby experiences any of these symptoms- hyperactivity, uncontrolled shaking, abnormal sleep, diarrhea, failure to gain weight or vomiting. 

Inform your doctor if you have any symptoms such as mental changes, runny nose, muscle aches, trouble sleeping, anxiety, sweating, or sudden changes in behavior.

Drug interaction with Hydrocodone

Patients consuming anticholinergic, other opioids, antihistamines, alcohol, anti-anxiety agents, anti-psychotics, or other CNS depressants along with Hydrocodone may experience an additive central nervous system depression. Hydrocodone can also interact with serotonergic drugs.

While many medicines can interact with Hydrocodone, some examples are:

  • Anti-seizure medications, like topiramate (Topamax, Qudexy XR, others), carbamazepine (Carbatrol, Tegretol, others), and lamotrigine (Lamictal)
  • alcohol
  • Benzodazepines, such as clonazepam (Klonopin), diazepam (Valium), alprazolam (Xanax), and lorazepam (Ativan) 
  • Certain antibiotics like clarithromycin
  • Some antidepressants
  • Certain antifungals, including an ketoconazole ,voriconazole (Vfend), itraconazole (Onmel, Tolsura), and voriconazole (Vfend) 
  • Some antiretroviral medications used for HIV infection, including ritonavir (Norvir), atazanavir, and indinavir (Crixivan) 
  • Medicines for sleeping problems, like zolpidem, eszopiclone, and zaleplon 
  • Medicines used to treat psychiatric problems, like haloperidol, clozapine, aripiprazole, and quetiapine 
  • Drugs used to treat nerve pain, like gabapentin and pregabalin

Possible side effects of Hydrocodone

Respiratory depression is likely to happen during the first one to three days of Hydrocodone medication, after a dosage rise, or if a high amount of Hydrocodone is taken. Children, older people, or those with existing respiratory conditions are likely to be more at risk. Respiratory depression can cause death.

Stopping Hydrocodone suddenly in a person who has become physically dependent on it may lead to withdrawal symptoms like irritability, pupil dilation, restlessness,  a runny nose, watery eyes, muscle aches, sweating, insomnia, gastrointestinal complaints, like vomiting, abdominal pain, diarrhea, or nausea. Children born to women who are dependent on Hydrocodone will also be dependent on Hydrocodone physically.

Get emergency medical help if you show allergic reaction symptoms to Hydrocodone: difficult breathing; hives; swelling of your throat, lips, face, or tongue.

Opioid medicine can lead to breathlessness and even death. A person caring for you must seek emergency medical attention or give naloxone if you have difficulty in breathing, if you are hard to wake up, or have blue-colored lips.

Call your doctor immediately if you have:

  • noisy breathing, breathing that stops during sleep, sighing, shallow breathing;
  • a slow heart rate;
  • a light-headed feeling;
  • confusion, or unusual thoughts.