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Dilaudid is a pain-relieving drug. Dilaudid is used to manage severe pain when other non-opioid pain medicines do not work for your pain. However, it would be best to use this drug cautiously and as directed because it may have possible side effects and withdrawal symptoms.

What is Dilaudid?

Dilaudid is available as the brand name for hydromorphone hydrochloride. Dilaudid is available in the tablet as well as oral solution form. Dilaudid is an opioid pain medicine. An opioid is also called a narcotic. It acts by altering the way the central nervous system (CNS) and the brain respond to pain. You may buy Dilaudid online from our website to relieve your pain. However, if you use hydromorphone for a long time, it can become habit-forming, causing physical or mental dependence.

Dilaudid is an opioid agonist, and it binds to several opioid receptors. The analgesic characteristics of Dilaudid are through its effect on the body’s mu-opioid receptors. Dilaudid also works centrally at the level medulla, suppressing cough and depressing the respiratory drive.

What important information should I know before using Dilaudid?

Dilaudid Tablets and Dilaudid Oral Solution contain hydromorphone. Hydromorphone is a substance with a high potential for misuse or abuse similar to other opioids like oxycodone, hydrocodone, morphine, tapentadol, and methadone.

Dilaudid Tablets and Dilaudid Oral solutions may be abused and are subject to addiction, misuse, and criminal diversion. Some signs of Dilaudid abuse are drowsiness, constricted pupils, mood swings, slowed breathing, and loss of alertness.

In some cases, extreme addiction can develop, characterized by hazardous behaviors, cravings, problems at school, work, home, and relationship issues. As an individual develops tolerance to Dilaudid, he would need increased and more frequent doses to achieve the desired high.

Tolerance, dependence, and withdrawal

As the person taking Dilaudid for an extended period stops taking the medication, his body requires time to recover. This causes withdrawal symptoms.

Dilaudid withdrawal can cause symptoms like:

Early symptoms include agitation, muscle aches, runny nose, sweating, and anxiety.

Late symptoms include abdominal cramping, dilated pupils, nausea, diarrhea, and goosebumps.

These withdrawal symptoms are pretty uncomfortable, but they aren’t life-threatening. Withdrawal symptoms generally start within twelve hours of the last Dilaudid usage.

Warnings and precautions

For patients with acute, chronic pulmonary disease

Dilaudid tablet treated or Dilaudid oral solution patients with severe chronic obstructive pulmonary disease and significantly reduced respiratory reserve, hypercapnia, or hypoxia are at increased risk of decreased respiratory drive. Such patients should strictly follow their doctor’s direction while taking Dilaudid.

For Elderly or debilitated patients

Life-threatening is more likely in elderly or debilitated patients as they can have altered clearance than healthier or younger patients. Such patients must be monitored closely, particularly when titrating and initiating Dilaudid Tablets or Dilaudid Oral solution and when this medication is given concomitantly with other medicines that depress respiration.

For patients with gastrointestinal problems

Dilaudid Tablets or Dilaudid Oral Solutions are contraindicated in people with suspected or known gastrointestinal obstruction. The hydromorphone in Dilaudid tablets or Dilaudid oral solution can cause spasms of the sphincter of Oddi.

For patients with seizure disorders

The hydromorphone in Dilaudid Tablets or Dilaudid Oral Solution can increase the frequency of seizures among patients with seizure disorders. Therefore, patients with a history of seizure disorders should be monitored for worsened seizure control during Dilaudid tablets or Dilaudid oral solution therapy.

Don’t use Dilaudid if you have used a monoamine oxidase inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include linezolid, isocarboxazid, methylene blue injection, rasagiline, phenelzine, selegiline, tranylcypromine, etc.

Certain medicines can interact with hydromorphone and cause a serious condition called serotonin syndrome. Ensure that your doctor knows if you also take medication for depression, mental illness, serious infections, Parkinson’s disease, migraine headaches, or prevention of nausea and vomiting. Consult your doctor before making any changes in how or when you take your medications.

To make sure hydromorphone is safe for you, tell your doctor if you have:

  1. noisy breathing, sighing, shallow breathing, breathing that stops during sleep;
  2. a history of head injury, brain tumor, or seizures;
  3. a history of drug abuse, alcohol addiction, or mental illness;
  4. urination problems;
  5. liver or kidney disease;
  6. sulfite allergy;
  7. Addison’s disease or other adrenal gland disorders; or
  8. problems with your gallbladder, pancreas, or thyroid.

How should I use Dilaudid?

Take Dilaudid exactly as your doctor directed you to. Dilaudid may stop or slow your breathing, especially when you start using this medicine or change your dose. Do not use Dilaudid in larger amounts or for longer than prescribed. Inform your doctor if Dilaudid seems to stop working as well in relieving your pain.

Dilaudid can be habit-forming, even at regular doses. Take this medicine precisely as suggested by your doctor. Misuse of narcotic pain medication can cause overdose, addiction, or even death.

Measure the Dilaudid liquid medicine with a special dose-medicine cup or measuring spoon, not with a regular tablespoon. If you don’t have a dose-measuring device, you can ask your pharmacist for one.

Don’t stop using Dilaudid suddenly, or you could have unpleasant withdrawal symptoms. Discuss with the doctor how to safely stop using this medicine.

Never break or crush a tablet to inhale the powder or mix it into a liquid to inject the Dilaudid drug into your vein. This practice has resulted in death due to the misuse of hydromorphone and similar prescription drugs.

Store Dilaudid at room temperature away from light, heat, and moisture. Discard any unused liquid after 90 days.

Keep track of the amount of drug used from each new bottle. Dilaudid is a drug of abuse. You must be aware if anyone is misusing your medicine.

Don’t keep leftover Dilaudid tablets or liquid. Ask your pharmacist where to locate a medication take-back disposal program. If there is no such take-back program, flush any unused liquid or tablets down your toilet. Disposal of drugs by flushing is recommended to minimize the danger of accidental overdose causing death. This advice is applicable for a minimal number of medicines only. The Food and Drugs Administration, working with the manufacturer, has determined this technique to be the most appropriate disposal route and presents the least risk to human safety.

What should I avoid while using Dilaudid?

Don’t drink alcohol. Hazardous side effects or death can occur when alcohol is combined with the hydromorphone in Dilaudid.

Dilaudid may impair your thinking or reactions. Avoid operating heavy machinery or driving till you know how Dilaudid affects you. Severe drowsiness or dizziness can cause falls or other accidents.

Dosage information of Dilaudid

DILAUDID Oral Solution: 5 mg/5 mL (1 mg/mL) of hydromorphone hydrochloride in a clear, colorless to pale yellow, slightly viscous liquid.


  1. 2 mg tablets (light orange, round, flat-faced tablets, with beveled edges, debossed with a “P” on one side and the number “2” on the opposite side)
  2. 4 mg tablets (light yellow, round, flat-faced tablets, with beveled edges, debossed with a “P” on one side and the number “4” on the opposite side)
  3. 8 mg tablets (white, triangular-shaped tablets, debossed with a “P” and an inverted “P” separated with a bisect on one side of the tablet and debossed with the number “8” on the other side of the tablet)

Dilaudid is available in tablet form in 8 milligrams strength, in liquid form in 5 milligrams per 5 milliliters of the solution, and Dilaudid injection is available as a sterile solution that contains 1, 2, or 4 milligrams hydromorphone hydrochloride with 0.2% citric acid solution and 0.2% sodium citrate.

Dosage of tablets generally begins at 2 to 4 milligrams every four to six hours; liquid dosage begins at 2.5 milligrams (2.5 milliliters) every three to six hours and can be modified depending on the patient’s response also on the doctor’s suggestion. Dilaudid injection starting dose is 1 to 2 milligrams intramuscularly or subcutaneously every four to six hours as required for pain. Dilaudid injection can also be given slowly over two to three minutes, but the patient’s respiration needs to be monitored.

Side effects of Dilaudid

Some of the common side effects of Dilaudid are nausea, light-headedness, vomiting, dry mouth, flushing, itching, diarrhea, stomach pain, strange dreams, dizziness, and drowsiness.

Severe side effects of Dilaudid include seizures (convulsions), trouble breathing, high body temperature, confusion, slow heart rate, cold and clammy skin, stiff muscles, difficulty walking, and shallow, weak, or slow breathing. Some of these effects may reduce after using Dilaudid medication for a while. However, if any of these persist, you should consult your pharmacist or doctor. Tell your pharmacist or doctor if you experience symptoms of an allergic reaction: swelling of lips, face, throat, or tongue. Narcotic medicines may stop or slow your breathing.

Get medical attention if you have symptoms of serotonin syndrome, like agitation, fever, hallucinations, sweating, fast heart rate, shivering, muscle stiffness, loss of coordination, or twitching. Older adults and patients who are debilitated or malnourished are more prone to severe side effects. Prolonged use of Dilaudid can affect fertility ( ability to have children) in women or men. It is not known if the results of Dilaudid medication on fertility are permanent.

After a few weeks of Dilaudid usage, patients can develop physical dependence and tolerance to the drug. They may need to be weaned off Dilaudid medication slowly to prevent addiction and withdrawal symptoms.

Drug interactions of Dilaudid

Hydromorphone interacts with many other drugs and causes dangerous side effects or death. Be sure your doctor knows if you also use:

  1. other narcotic medications – opioid pain medicine or prescription cough medicine;
  2. a sedative like Valium – diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;
  3. drugs that make you sleepy or slow your breathing – a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or
  4. drugs that affect serotonin levels in your body – a stimulant or medicine for depression, Parkinson’s disease, migraine headaches, serious infections, or nausea and vomiting.

This list is not complete. Other drugs may affect hydromorphone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.